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Naked DNA Vaccine Protects 1 of 4 Monkeys Against SHIV

Published in AIDS Weekly, April 10th, 1995

A naked DNA HIV vaccine protected one of four monkeys against massive challenge with an infectious HIV/SIV hybrid virus.

The vaccine is being developed by a research team led by David B. Weiner of the University of Pennsylvania in collaboration with Apollon Inc., Malvern, Pennsylvania. Weiner's group recently received a four-year, $4.2 million grant from the U.S. National Institute of Allergy and Infectious Diseases (NIAID) to develop naked DNA for use as an AIDS therapy.

Weiner presented preliminary findings from nonhuman primate studies of the vaccine at two recent conferences: the Third Annual Vaccines: New Technologies and Applications...

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