"HIV Infection of Human Fetal Thymic Organ Cultures."

According to an abstract submitted by the authors to the Annual Meeting of Professional Research Scientists entitled Experimental Biology 95, held April 9-13, 1995, in Atlanta, Georgia, "A major target for viral infection in the course of HIV pathogenesis is the thymus, the central site for T lymphocyte differentiation. It has been previously demonstrated that HIV infection of thymic tissue results in an aberrant depletion of mature T lymphocytes However, the pathogenic mechanisms of HIV upon T lymphocyte maturation remain unknown. To study the effects of HIV on the pathways of T cell differentiation, we developed a human fetal thymic organ culture (FTOC) system. Briefly, human fetal...

Want to see the full article?

• Purchase this article for only $3.00