"Context-Dependent Peptide Presentation."

According to an abstract submitted by authors to the Keystone Symposium Control and Manipulation of the Immune Response, held March 16-22, 1995, in Taos, New Mexico, "Helper T lymphocytes recognize antigenic peptides in association with class II MHC molecules on the surface of antigen presenting cells (APC). Recognition of an antigen thus requires its internalization and processing by the APC. Little is known about the process by which antigenic fragments are generated and delivered to class II molecules. Evidences from various antigen systems suggest that antigen processing can be one factor that determines the repertoire of immunogenic peptides. In the present study, we tested a...

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