"Loss of CD28 Expression is Associated with Replicative Senescence of T Cells In Vitro and In Vivo."

According to an abstract submitted by authors to the Keystone Symposium Control and Manipulation of the Immune Response, held March 16-22, 1995, in Taos, New Mexico, "The immune deficiency of aging is characterized by a dramatic decline in functions requiring T cell proliferation. We have studied the long-term proliferative potential of normal human T lymphocytes which are repeatedly activated with antigen and cultured in the continuous presence of Interleukin-2. Experiments on more than 200 individual cultures derived from 10 different donors have shown that T cells, like all other normal cells, have a limited replicative lifespan before reaching a state of senescence. The senescent T...

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