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Therapy/Retinoic Acid

Ex Vivo CD4+ Cell Death Reduced in AIDS Patients Receiving Retinoic Acid

Published in AIDS Weekly, May 1st, 1995

CD4+ T cells cultured from HIV+ patients had reduced spontaneous cell death after they received all-trans-retinoic acid (tRA), report researchers from the U.S. National Cancer Institute (NCI).

The findings indicate that tRA may affect what is thought to be a major cause of the drastic depletion of CD4+ T cells characteristic of AIDS: the induction of programmed cell death, or apoptosis, by HIV.

Apoptosis is a normal mechanism in which cells no longer needed by the body undergo a process of DNA degradation and death. Several researchers, most notably HIV discoverer Luc Montagnier, believe that HIV kills far...

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