"Functional Studies of Epidermal Langerhans Cells and Blood Monocytes in HIV-Infected Persons."

According to the authors' abstract of an article published in Journal of Immunology, "APC dysfunction may be important in immune dysregulation associated with HIV disease. Langerhans cells, epidermal APC, can be infected with HIV, although their function in HIV-infected persons has not been studied. Therefore, we studied the immunologic function of Langerhans cells, in parallel with blood APC (enriched for monocytes/macrophages (M phi)) function, in 21 HIV-seropositive (HIV⁺) and 21 HIV-seronegative volunteers, including three monozygotic twin pairs discordant for HIV serology. Langerhans cells from HIV⁺ patients were quantitatively normal and expressed normal...

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