"Induction by Human Immunodeficiency Viruses Types 1 and 2 of Degradation of CD4 But Not of a CD4 Mutant Unable to Bind Viral Envelope Glycoproteins."

According to the authors' abstract of an article published in Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, "HIV-1 appears to use a multiple gene strategy to regulate CD4 receptor expression, which emphasizes the importance of this regulation in the viral life cycle. The cytoplasmic interaction between gp160 and CD4 is probably the major event governing CD4 down-regulation, although other viral proteins, such as Nef (CD4 cell surface localization) and Vpu (CD4 degradation), are thought to participate as well. Because of the lack of vpu in HIV-2, we investigated the effects of two HIV-2 isolates (##ROD 10## and ##EHO##) on CD4 expression in the CEM T-cell line. ...

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