Disease Progression

Hyper-IgE Linked to Clinical Signs of HIV Infection

Published in AIDS Weekly, June 19th, 1995

Hyperimmunoglobulinemia E-like syndrome represents a distinct aspect of the clinical manifestations associated with HIV infection, according to a report from Italy.

Researcher Roberto Paganelli and colleagues found that the immunologic mechanisms in this condition seem to differ from those known in primary hyper-IgE syndrome because CD4 T H2 type cells, which are currently believed to have a role in IgE production, are severely depleted in HIV-positive patients ("Immunologic Aspects of Hyperimmunoglobulinemia E-Like Syndrome in Patients with AIDS," Journal of Allergy and Clinical Immunology, May 1995;5(1):995-1002).

Hypereosinophilia accompanied by...

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Source: AIDS Weekly (1995-06-19)

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