Published in AIDS Weekly, June 26th, 1995
The drug is 1-(11-octylamino-10-hydroxyundecyl)-3,7-dimethylxanthine, or commonly known as CT-2576. CT-2576 inhibits HIV expression in U1 cells at a 50% inhibitory concentration (IC50 ) of 1 (mu)M. An acetylated derivative of CT-2576, CT-3537, inhibits HIV expression at similar concentrations.
Because CT-2576 is targeted to the cells of an infected person and not to the virus itself, this approach should not give rise to the drug-resistant viral mutants that limit the efficacy of other antiretroviral agents.
"In view of the...
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