HIV Gene Therapy
Fusion Protein Trev Represents Potent Novel Molecule
Published in AIDS Weekly, July 10th, 1995
E. Aguilar-Cordova and colleagues, Baylor College of Medicine, Houston, Texas, said that they constructed a double transdominant fusion gene (trev) that was designed to inhibit simultaneously two essential HIV functions ("Inhibition of HIV-1 by a Double Transdominant Fusion Gene," Gene Therapy, 1995;2:181-186). This was achieved by linking tat and rev transdominant mutants.
"Trev independently inhibited both Tat and Rev functions, localized within the nucleus and cells transfected with trev...
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Source: AIDS Weekly (1995-07-10)
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