Pathogenesis

CTL Activity May Help Control HIV-2 Replication

Published in AIDS Weekly, July 17th, 1995

Cytotoxic T-lymphocyte (CTL) activity appears to be important in the control of HIV-2 replication, according to a report from West Africa.

Cytotoxic T-lymphocytes are believed to play an important role in eradicating virus in infected cells during acute infection and in controlling viral replication in persistent infection. It is also possible, however, that excess CTL activity may contribute to the immunopathogenesis of AIDS.

"Recent studies have shown that the rapid reduction of primary plasma viraemia is associated with the presence of HIV-1-specific CTL," researcher Koya Ariyoshi and colleagues wrote ("HIV-2-Specific Cytotoxic T-Lymphocyte...

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Source: AIDS Weekly (1995-07-17)

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