Published in AIDS Weekly, July 24th, 1995
It has recently been reported that nonnucleoside inhibitors of HIV-1 reverse transcriptase (RT) may be useful in AIDS chemotherapy. These derivatives exhibit high selectivity for HIV-1 RT but do not inhibit HIV-2 or any other nucleic acid polymerase. A number of such agents are being investigated in clinical trials, including tetrahydroimidazobenzodiazepinthiones (TIPO), dipyridodiazepinones, pyridinones, bisheteroarylpiperazines and (alpha)-anilidophenylacetamides.
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