Drug Development

Anti-HIV Sulfated Sugar Compounds Make a Comeback

Published in AIDS Weekly, August 14th, 1995

New sulfated oligosaccharide compounds with potent anti-HIV activity have excellent pharmacokinetic profiles.

Earlier in the AIDS epidemic, sulfated polysaccharide compounds such as dextran sulfate were found to have powerful anti-HIV activities. However, these drugs' anticoagulant effects, poor absorbance, and instability eventually eliminated them from consideration as AIDS therapeutics.

T. Uryu of the University of Tokyo, Japan, and colleagues reported in 1992 that alkylation of sulfated oligosaccharides yielded compounds with in vitro anti-HIV activities similar to those seen with sulfated polysaccharides (DeNoon, 1995; "AIDS Therapies: ...

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Source: AIDS Weekly (1995-08-14)

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