Published in AIDS Weekly, September 18th, 1995
It has been suggested that an attenuated virus vaccine might induce effective, long-lasting immunity in an immunized host, but there is also the possibility of a conversion of the attenuated virus to a virulent form. In a 1992 study Daniel et al. reported that an attenuated, Nef-deleted simian immunodeficiency virus (SIV) effectively protected rhesus macaques against other kinds of SIV challenge (Science 1992;258:1938-1941). Because the level of humoral antibodies was low it was...
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