HIV Vaccines

DNA-Based Immunization May Have Efficacy in HIV Prevention

Published in AIDS Weekly, September 18th, 1995

Injection of HIV-1 gene expression plasmids can induce potent humoral and cell-mediated immune responses and suggest that DNA vaccines may have efficacy in the immunization against HIV-1.

It has been suggested that an attenuated virus vaccine might induce effective, long-lasting immunity in an immunized host, but there is also the possibility of a conversion of the attenuated virus to a virulent form. In a 1992 study Daniel et al. reported that an attenuated, Nef-deleted simian immunodeficiency virus (SIV) effectively protected rhesus macaques against other kinds of SIV challenge (Science 1992;258:1938-1941). Because the level of humoral antibodies was low it was...

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Source: AIDS Weekly (1995-09-18)

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