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HIV Vaccines

"The Evolving Molecular Epidemiology of HIV-1 Envelope Subtypes in Injecting Drug Users in Bangkok, Thailand: Implications for HIV Vaccine Trials."

Published in AIDS Weekly, September 25th, 1995

According to the authors' abstract of an article published in AIDS, "Objective: To genetically characterize HIV-1 strains in injecting drug users (IDU) in Bangkok, Thailand in 1994, and compare these with strains found earlier in Thai IDU; such information is essential for HIV-1 vaccine development and evaluation. Methods: Peripheral blood mononuclear cells were collected from 84 IDU attending 14 drug treatment clinics in Bangkok in 1994. DNA was amplified using a nested polymerase chain reaction (PCR) procedure and sequenced directly (without cloning) from the PCR products. The V3 and flanking regions (345 nucleotides) of the env gene were analyzed using a...

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