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AIDS Therapies

AZT Reduces Brain Lesions in AIDS Patients

Published in AIDS Weekly, October 30th, 1995

Zidovudine can significantly reduce the incidence of HIV induced brain lesions in AIDS patients if continued until death, according to a decade-long study from Norway.

Several neuropathological studies have concluded that zidovudine treatment reduces the frequency of HIV induced brain lesions in AIDS patients, and may also reduce the incidence of AIDS dementia. The neuroprotective effect of zidovudine, however, has varied with individual studies. In one study brain lesions actually increased in patients treated with zidovudine (Davies et al., Clin Neuropathol 1993,12(suppl 1):9).

In this study, researcher Jan Maehlen and colleagues investigated the...

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