HIV Gene Therapy
New Wave Protease Inhibitor Would Avoid Resistance
Published in AIDS Weekly, December 4th, 1995
Researchers Lilia M. Babe et al. of the University of California, San Francisco, report the development of dominant negative HIV genes that express inactive forms of the HIV protease gene, thereby disrupting viral replication ("Trans-Dominant Inhibitory Human Immunodeficiency Virus Type 1 Protease Monomers Prevent Protease Activation and Virion Maturation," Proceedings of the National Academy of Sciences, October 24, 1995;92(22):10069-73).
Dominant negative mutants have been developed for...
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Source: AIDS Weekly (1995-12-04)
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