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Trials to Explore Use of MAbs in Children of HIV+ Women

Published in AIDS Weekly, December 18th, 1995

What some call the new wave in passive immunity - human monoclonal antibodies (MAbs) - will be tested for their ability to protect children born to women with HIV infection.

Unlike natural polyclonal antibodies produced by humans or animals inoculated with antigens, MAbs are tailored to recognize only highly specific epitopes. MAbs represent an exciting new frontier in AIDS therapy because they can do - at least in the test tube - something the human immune response can rarely if ever achieve: neutralize widely different strains of HIV.

Diane Wara of the University of California, San Francisco, and George McSherry of the University of Medicine and...

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