HIV Gene Therapy
"Autocrine Interferon-Beta Synthesis for Gene Therapy of HIV Infection: Increased Resistance to HIV-1 in Lymphocytes from Healthy and HIV-Infected Individuals."
Published in AIDS Weekly, December 18th, 1995
According to the authors' abstract of an article published in AIDS, "Objective: To explore the possibility of gene therapy of HIV infection based on the multiple antiretroviral activities of interferon (IFN)-beta. Design: We introduced into HIV target cells an IFN-beta gene placed under an expression control ensuring a low and constitutive expression, sufficient to confer a permanent antiviral state without impeding normal cell function. Methods: We transformed, with an efficacy ranging from 20-55%, peripheral blood lymphocytes (PBL) derived from healthy, seronegative donors, and from asymptomatic HIV-infected individuals by the HMB-K(b)HuIFN beta retroviral...
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Source: AIDS Weekly (1995-12-18)
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