AIDS Therapies
"Compounds that Target Novel Cellular Components Involved in HIV-1 Transcription."
Published in AIDS Weekly, January 29th, 1996
According to the authors' abstract of an article published in Molecular Medicine, "Background: Therapeutic intervention designed to block expression of human immunodeficiency virus (HIV) at a cellular level may slow the clinical progression of HIV-1 disease. Materials and Methods: Cellular models of latent (OM-10.1 and U1) and chronic (8E5) HIV infection were used to evaluate two benzothiophene derivatives, PD 121871 and PD 144795, for an ability to inhibit HIV activation and expression. Results: The benzothiophene derivatives were effective at micromolar concentrations in preventing tumor necrosis factor alpha (TNF alpha)-induced HIV-1 expression in OM-10.1...
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Source: AIDS Weekly (1996-01-29)
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