Pathogenesis
"Fas (CD95) Expression on CD4+ T Cells from HIV-Infected Patients Increases with Disease Progression."
Published in AIDS Weekly, February 5th, 1996
According to the authors' abstract of an article published in Journal of Molecular Medicine - Jmm, "Active T-cell suicide (apoptosis) is supposed to be involved in the CD4+ T-cell depletion in the course of HIV infection. We investigated the expression of the apoptosis-related antigen Fas on CD4+ T cells from 25 HIV-positive individuals (CDC I-III) and 8 HIV-negative controls by two-colour flow cytometry. In addition, we evaluated: total CD4 count, HIV p24 antigen concentration in serum after immune complex dissociation, and clinical course of infection in HIV-positive individuals. We found a significant increase in mean Fas expression on CD4+ T cells...
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Source: AIDS Weekly (1996-02-05)
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