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HIV Gene Therapy

Virion-Targeted Viral Inactivation Weakens HIV

Published in AIDS Weekly, February 19th, 1996

A unique HIV gene therapy protocol utilizes virion-targeting for viral inactivation.

Although twisty, elusive and capable of mutating quickly, the HIV infection cycle actually provides multiple opportunities for therapeutic intervention.

G. Pignac-Kobinger et al. submitted data at the 3rd Conference on Retroviruses and Opportunistic Infections, held January 28 - February 1, 1996, in Washington, D.C., which suggested that virion-targeted viral inactivation may provide a unique opportunity to interfere with HIV viral replication.

"In this strategy, a deleterious amino acid sequence is fused to a virion-associated component to...

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