"Surveillance of HIV-1 Subtypes in 222 U.S. Blood Donors: Identification of First U.S. Subtype A Infection."

According to an abstract submitted by the authors to the 3rd Conference on Retroviruses and Opportunistic Infections, held January 28 - February 1, 1996, in Washington, DC, "Background: Failure of anti-HIV assays to detect variant HIV subtypes (eg, HIV-1 group O) necessitates surveillance for rare subtypes among US donors. To date, all HIV-1 characterized in the US is subtype B, except one case of subtype D. Methods: DNA was extracted from leukocytes from 100 donors identified in 1984 and 122 donors from 1994. A region of gp120 was amplified by nested PCR, and hybridized separately to cloned prototype sequences for subtypes A-F. Primary typing was based on migration...

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