Conference Coverage (NCVDG)

Targeted Lymph Node Immunization Protects Against Rectal Challenge

Published in AIDS Weekly, March 25th, 1996

Monkeys immunized via direct iliac lymph-node inoculation were protected against rectal challenge with simian immunodeficiency virus (SIV).

The findings provide insight into ways vaccines might be used to prevent the sexual transmission of HIV.

"No single immune response is protective," said researcher Thomas Lehner of Guys Hospital, London, England.

"We suggest that three successive immune barriers, from the epithelium, towards the iliac lymph nodes, and then the circulating immune cells and antibodies may each play a part in preventing viral transmission or decreasing the viral load."

Lehner reported the...

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Source: AIDS Weekly (1996-03-25)

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