HIV Gene Therapy
"Intracellular Immunization Against SIV-mac Utilizing a Hairpin Ribozyme."
Published in AIDS Weekly, March 25th, 1996
According to the authors' abstract of an article published in Virology, "A hairpin ribozyme targeting the 3' LTR region (9456) of SIVmac239 was cloned into a murine retroviral vector. This target sequence is conserved among various SIV, as well as most HIV-2, strains. The ribozyme cassette is driven from a polymerase III promoter, that of the human tRNAval gene. Hybrid human B-/T-cell lines (CEM/174) were transduced with the retroviral constructs and selected for G418 resistance. Cells stably expressing the 9456 ribozyme exhibited long-term resistance to infection by a pathogenic molecular clone of SIV and two strains of HIV-2. The ribozyme was also able to effectively reduce the...
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Source: AIDS Weekly (1996-03-25)
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