Pharmacokinetics
"Increased Plasma Rifabutin Levels with Concomitant Fluconazole Therapy in HIV-Infected Patients."
Published in AIDS Weekly, April 22nd, 1996
According to the authors' abstract of an article published in Annals of Internal Medicine, "Objective: To determine the effect of fluconazole on rifabutin pharmacokinetics. Design: An open-label, crossover, Phase 1 trial. Setting: Outpatient clinical research center at a university medical center in Washington, D.C. Patients: 12 persons with human immunodeficiency virus (HIV) infection whose CD4 lymphocyte counts were between 200 and 500 cells/mm3 and who were receiving maintenance therapy with zidovudine. Intervention: Fluconazole, 200 mg/d for 2 weeks; then a combination of fluconazole, 200 mg/d, and rifabutin, 300 mg/d, for 2...
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Source: AIDS Weekly (1996-04-22)
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