AIDS Therapies (AZT)

Analog Shows Antiviral Activity in Cell Culture

Published in AIDS Weekly, May 13th, 1996

An azidothymidine analog has "... conferred protection to macrophages against retroviral infection," scientists reported in the April 30, 1996, issue of the Proceedings of the National Academy of Sciences (Proc Natl Acad Sci 1996;93:4403-4408).

Dr. Mauro Magnani in Urbino, Italy, and colleagues have identified "... the chemical synthesis, characterization, macrophage-targeted delivery, and antiretroviral activity of a new ... AZT homodinucleotide."

According to Magnani, the addition of azidothymidine homodinucleotide-loaded erythrocytes to human, feline and murine macrophages "... afforded almost complete in vitro protection of these cells from...

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Source: AIDS Weekly (1996-05-13)

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