"Randomized Study of the Tolerance and Efficacy of High- Versus Low-Dose Zidovudine in Human Immunodeficiency Virus-Infected Children with Mild to Moderate Symptoms (AIDS Clinical Trials Group 128 RIGHTPAR

According to the authors' abstract of an article published in Journal of Infectious Diseases, "The current dosage of zidovudine for children is 180 mg/m² every 6 h, To investigate whether a lower dosage was equally effective, human immunodeficiency virus (HIV)-infected children (3 months to 12 years) with mild to moderate symptoms were randomly assigned to receive either high-dose (180 mg/m²/dose) or low-dose (90 mg/m²/dose) zidovudine (double-blind). Treatments were compared with respect to neuropsychologic function, survival, clinical and laboratory evidence of disease progression, and safety and tolerance. Four hundred twenty-six HIV-infected children...

Want to see the full article?

• Purchase this article for only $3.00