Published in AIDS Weekly, June 17th, 1996
Ribozymes are RNA molecules with enzymatic activity and have great potential as therapeutic entities because of their ability to either cleave deleterious RNA transcripts or repair mutant cellular RNAs. Certain catalytic ribozymes can cut and splice RNAs inside cells, modifying the encoded genetic information.
Development of ribozymes as therapeutic agents in vivo has been hampered by the inability to directly identify and characterize ribozyme reaction products in mammalian cells. Joshua T. Jones et al. developed an...
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