Conference Coverage (Vancouver)

AIDS Pathogenesis Debate: Vital Questions for Vaccine Research

Published in AIDS Weekly, August 5th, 1996

Is the main determinate of HIV disease the virulence of the virus or the susceptibility of the infected person'

This unresolved question looms large in the quest for an HIV vaccine.

"It's the virus, stupid," says David Ho of New York's Aaron Diamond Research Center.

If so, an ideal HIV vaccine would elicit immune responses - neutralizing antibodies and/or cytotoxic lymphocytes (CTLs) - that directly attack the virus.

"Host factors are critical determinants of the resistance to pathogens and of the subsequent clinical outcome," says Giuseppe Pantaleo of the National Institute of Allergy and Infectious Diseases,...

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Source: AIDS Weekly (1996-08-05)

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