Published in AIDS Weekly, August 12th, 1996
Monkeys protected against simian immunodeficiency virus (SIV) infection by a live attenuated SIV vaccine developed cytotoxic lymphocyte (CTL) responses specific for the SIV Nef protein - even though the vaccine lacked a functional nef gene.
It appeared that the initial dose of the live vaccine influenced the animals' susceptibility to challenge. Other monkeys given lower doses of the vaccine became infected and did not exhibit post-challenge anti-Nef CTL.
"Taken together, the results suggest that specific or innate responses that suppress...
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