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Commentary

Protease Inhibitors: The Good and the Bad

Published in AIDS Weekly, August 19th, 1996

There is still no cure for AIDS.

It says so right there in the patient-information section of the package inserts for the three U.S.- approved protease inhibitors: saquinavir (Hoffman-LaRoche's Invirase), indinavir (Merck's Crixivan), and ritonavir (Abbott's Norvir).

This remains true despite the widely held belief that people with HIV infection can indefinitely postpone disease by adding an HIV protease inhibitor to their treatment regimens.

There is solid evidence in support of this idea: as many as 90 percent of clinical-trial participants who receive a protease inhibitor plus zidovudine (AZT) plus lamivudine (3TC) have had...

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