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Immune Reconstitution Slow in Patients Taking Anti-HIV Drugs

Published in AIDS Weekly, August 19th, 1996

Patients receiving anti-HIV drugs have increased T-cell numbers, but the immune function of these new cells is impaired.

The hallmark of HIV disease is a marked decrease in CD4⁺ T cells. Antiretroviral therapies have long been evaluated in terms of their ability to reverse this trend.

But the new data suggest that clinicians will have to measure more than mere numbers to determine whether a patient's immune system has improved.

"An increase in T-cell counts is not necessarily associated with an increase in T-cell functional capacity," said Nadine G. Pakker of the Netherlands Red Cross Blood Transfusion Service,...

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Source: AIDS Weekly (1996-08-19)

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