AIDS Therapies (Onconase)

RNAse Cancer Drug Shows Promise for Inhibiting HIV

Published in AIDS Weekly, September 9th, 1996

In vitro findings published in the August 23, 1996, issue of Journal of Biological Chemistry (Vol. 271:2073-20788) revealed that Onconase significantly inhibited production of HIV-1 in several persistently infected human cell lines.

Onconase is an anticancer ribonuclease which degraded viral RNA while not affecting normal cellular ribosomal RNA and messenger RNAs. "These results demonstrate that Onconase, at non-cytotoxic concentrations, can effectively and selectively inhibit replication of [HIV] in vitro by more than 90 percent without necessarily killing the HIV harboring cell," stated Dr. Richard Youle, U.S. National Institute of Neurological Disorders and Stroke...

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Source: AIDS Weekly (1996-09-09)

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