HIV Vaccines

Weak Anti-Gag Antibodies Associated with Rapid CD4 Decline

Published in AIDS Weekly, November 11th, 1996

HIV infected individuals with weak anti-p55 antibodies are nearly eight times more likely to have rapid disease progression.

The data come from a study of Western blot reactivity patterns among U.S. Navy and Marine Corps personnel who tested positive for HIV between 1986 and 1991.

"This and a previous study [Nicholson et al., AIDS Res H, 1989;5:205] suggest that strong antibody responses to products of the gag gene are correlated with slower progression of HIV infection," wrote Frank C. Garland of the Naval Health Research Center, San Diego, California, and colleagues.

"If this association is causal rather than artifactual,...

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Source: AIDS Weekly (1996-11-11)

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