AIDS (Pathogenesis)

New Technique Finds HIV Hidden in Lymphoid Tissues

Published in AIDS Weekly, December 9th, 1996

There is much more HIV in the lymphoid tissues of an infected person than in the blood.

The bad news is that these infectious virions apparently are not affected by inhibitors of HIV reverse transcriptase.

The good news is that they can be measured by a new technique that can estimate HIV viral load in lymphoid tissues reliably from relatively non-invasive outpatient tonsil biopsies.

"Image analysis of the presymptomatic stage of HIV-1 infection in lymphoid tissue revealed a relatively spatially homogeneous and temporally stable pool of virions associated with follicular dendritic cells that exceeds the viral load in plasma by...

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Source: AIDS Weekly (1996-12-09)

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