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AIDS Therapies (MKC-442)

Preliminary Results Reported for MKC-442 Anti-HIV Drug

Published in AIDS Weekly, February 3rd, 1997

Preliminary clinical data on the anti-HIV drug MKC-442 (Triangle Pharmaceuticals, Inc., Durham, North Caroline) were presented at the Fourth Conference on Retroviruses and Opportunistic Infections, held in Washington, D.C., January 22-25, 1997.

The data were from an ongoing Phase Ib/IIa double-blind, placebo-controlled trial designed to evaluate the safety and efficacy of repeated multiple oral doses of MKC-442 in HIV infected patients. A total of 26 patients were treated for up to two months.

Doses ranging from 100 to 350 mg twice a day were given to groups of six patients at each dosage level and additional patients currently are entering the...

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