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Conference Coverage (Retrovirus)

HIV Lurks in Lymph Nodes During Triple Therapy

Published in AIDS Weekly, February 10th, 1997

Even when HIV RNA vanishes from the lymph nodes after aggressive treatment, proviral DNA persists.

Precisely how long the latent virus lurks is the question at the heart of whether HIV infection can ever be cured. Even though potent new treatments apparently eliminate HIV from the blood, the virus hides in the lymph nodes (and perhaps in other tissues) of infected individuals.

University of Minnesota researcher W. Cavert and colleagues used computerized quantitative image analysis coupled with in-situ hybridization (ISH) to detect evidence of HIV-1 in tonsil biopsies from ten patients with HIV infection.

They reported their...

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