Conference Coverage (Retrovirus)

HIV, Apoptosis Reduced in Mucosa During AIDS Therapy

Published in AIDS Weekly, February 10th, 1997

HIV and its damaging effects are greatly reduced in mucosal lymphoid tissues during potent combination antiretroviral therapies.

The findings are good news for people with access to the new treatments. They also provide new insights into the pathogenesis of HIV disease.

D.P. Kotler of St. Luke's-Roosevelt Hospital Center, New York, and colleagues previously showed that the presence of HIV in the intestinal mucosa is associated with clinical symptoms, tissue changes, deletion of CD4⁺ lymphocytes, cytokine expression, and, perhaps most importantly, apoptosis of mononuclear cells in the lamina propria (Gastro, 1992;103:919; Dig Dis Sci,...

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Source: AIDS Weekly (1997-02-10)

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