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Conference Coverage (Retrovirus)

IL-2 Prevents CD8+ Cell-Cycle Arrest

Published in AIDS Weekly, March 10th, 1997

A large proportion of CD8+ T lymphocytes in people with HIV infection are frozen at an early stage of the cell cycle.

Treatment with interleukin 2 (IL-2) apparently jump-starts this stalled process, according to R.A. Lempicki, H. Clifford Lane, and colleagues at the National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, Maryland.

"Administration of IL-2, in vivo or in vitro, may prevent cell cycle arrest and induce CD8+ T cells to progress normally through the cell cycle and to engage in proper effector function," Lempicki et al. wrote in the abstract of their presentation to the Fourth Conference on...

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