"CCR3 and CCR5 Are Co-Receptors for HIV-1 Infection of Microglia."

According to the authors' abstract of an article published in Nature, "Several members of the chemokine receptor family are used together with CD4 for HIV-1 entry into target cells. T-cell line-tropic (T-tropic) HIV-1 viruses use the chemokine receptor CXCR4 as a co-receptor, whereas macrophage-tropic (M-tropic) primary viruses use CCR5. Individuals with defective CCR5 alleles exhibit resistance to HIV-1 infection, suggesting that CCR5 has an important role in vivo in HIV-1 replication. A subset of primary viruses can use CCR3 as well as CCR5 as a co-receptor, but the in vivo contribution of CCR3 to HIV-1 infection and pathogenesis is unknown. HIV-1 infects the central nervous system...

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