HIV Vaccines
"Oral Immunization with Recombinant Mycobacterium bovis BCG Simian Immunodeficiency Virus nef Induces Local and Systemic Cytotoxic T-Lymphocyte Responses in Mice."
Published in AIDS Weekly, March 31st, 1997
According to the authors' abstract of an article published in Journal of Virology, "Recombinant live Mycobacterium bovis BCG vectors (rBCG) induce strong cellular and humoral immune responses against various antigens after either systemic or oral immunization of mice. Cytotoxic T-lymphocyte (CTL) responses may contribute to the control of human immunodeficiency virus (HIV) or simian immunodeficiency virus (SIV) infections whose portal of entry is the gastrointestinal or genital mucosa. In this study, we immunized BALB/c mice with a recombinant BCG SIV nef and observed its behavior in oropharyngeal and target organ lymphoid tissues. The cellular immune responses, particularly the...
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Source: AIDS Weekly (1997-03-31)
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