Kaposi's sarcoma (KSHV)
"A Single 13-Kilobase Divergent Locus in the Kaposi sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Genome Contains Nine Open Reading Frames That Are Homologous to or Related to Cellular Proteins. D
Published in AIDS Weekly, March 31st, 1997
According to the authors' abstract of an article published in Journal of Virology, "Two small fragments of a novel human gammaherpesvirus genome known as Kaposi's sarcoma (KS)-associated herpesvirus or human herpesvirus 8 (HHV-8) have been shown to be present in virtually all AIDS and non-AIDS KS lesions, as well as in body cavity-based lymphomas (BCBL) and in multicentric Castleman's disease. We have extended those studies by identifying and sequencing a third fragment of HHV-8 DNA encoding a viral thymidylate synthetase (TS) gene. Use of this viral TS fragment as a probe led to the identification and mapping of a cluster of overlapping phage lambda clones from a BCBL tumor DNA genomic...
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Source: AIDS Weekly (1997-03-31)
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