AIDS Therapies

HIV Replication Increased by Drugs That Prevent Cell Suicide

Published in AIDS Weekly, April 14th, 1997

Strategies to inhibit HIV induced programmed cell death or apoptosis may backfire.

New studies show that apoptosis may actually be a beneficial mechanism that limits the spread of HIV. Experimental inhibition of apoptosis actually enhanced in vitro and ex vivo HIV replication.

University of Michigan researchers Arul M. Chinnaiyan, Gary J. Nabel, and colleagues reported the findings in the journal Nature Medicine ("The Inhibition of Pro-Apoptotic ICE-Like Proteases Enhances HIV Replication," Nat Med, 1997;3(3):333-40).

"The results of this study suggest that inhibition of apoptosis may potentiate viral replication and that...

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Source: AIDS Weekly (1997-04-14)

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