Published in AIDS Weekly, April 21st, 1997
New studies suggest an answer, and provide a glimpse into the inner workings of the human immune system.
The recent discovery of the coreceptors required for HIV-1 entry into cells showed that macrophage-tropic (M-tropic) strains use the CCR5 receptor while T-lymphocyte-tropic (T-tropic) strains use the CXCR4 receptor (also known as fusin or Lestr).
M-tropic HIV strains predominate early in the course of infection; T-tropic strains predominate in the later stages of disease. Harvard researcher Conrad C. Bleul and colleagues have uncovered clues...
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