AIDS Pathogenesis
HIV, SIV Share CCR5 Coreceptor
Published in AIDS Weekly, April 21st, 1997
The finding suggests that HIV infectivity may depend on an extraordinarily well-conserved region of HIV. If so, the virus would likely be very limited in its ability to develop resistance to future drugs or vaccines exploiting this region.
"Human and simian CCR5 molecules are very closely related, with only four amino-acid differences in the extracellular sequences of these proteins," reported Harvard researcher Luisa Marcon and colleagues. "Both can serve as entry cofactors for HIV-1 and SIV."
Marcon et...
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Source: AIDS Weekly (1997-04-21)
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