"Lack of Chronic Immune Activation in HIV-Infected Chimpanzees Correlates with the Resistance of T Cells to Fas/Apo-1 (CD95)-Induced Apoptosis and Preservation of a T Helper 1 Phenoty

According to the authors' abstract of an article published in Journal of Immunology, "Chimpanzees are one of the few species, along with humans, susceptible to persistent HIV-1 infection. However, HIV-infected chimpanzees do not exhibit the marked immune system alterations seen in humans and remain relatively resistant to AIDS. In humans, HIV infection leads to unresponsiveness of T cells in response to TCR stimulation, associated with increased T-cell death by apoptosis. In an effort to understand some of the mechanisms used to limit lentivirus infection in African nonhuman primates, we compared apoptosis in infected humans vs chimpanzees in CD4 and CD8 T cells in relation with the...

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