Dental Vaccines

Cavity-Fighting Vaccine Goes to Work in Gut

Published in AIDS Weekly, May 5th, 1997

A genetically engineered vaccine against dental cavities induces T helper cells in the gut, stimulating the common mucosal immune system and resulting in circulating and mucosal antibodies.

The vaccine targets the dental cavity-causing bacteria Streptococcus mutans, which sticks to teeth via an adhesin on its surface called AgI/II (also known as antigen B, P1, SpaP, and PAc). The saliva-binding region (SBR) of AgI/II is therefore an attractive vaccine antigen.

But to stimulate antibodies where they will do the most good, a dental vaccine has to elicit secretory immunoglobulin A (sIgA) in the saliva. This must be done by stimulating the...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of AIDS Weekly

Source: AIDS Weekly (1997-05-05)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry