"Immune Response to an Immunogen Representing the Variability of the HIV-1 Envelope Glycoprotein."

According to an abstract submitted by the authors to the Keystone Symposia on Molecular and Cellular Biology entitled AIDS Pathogenesis, sponsored by Abbott Laboratories and the Director's Sponsor Fund, held April 8-13, 1997, in Keystone, Colorado, "Design and development of synthetic vaccines against HIV-1 has been delayed by the absence of a technology capable of overcoming epitope variability by immunization. We have designed and prepared a complex synthetic immunogen which represents the in vivo variation seen on all the major hypervariable epitopes on the envelope glycoprotein (8p 120) of HIV-1. Sera from HIV-1 positive patients from different countries were used to test if...

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