Animal Models (HIV)
"Animal Model of Mucosally Transmitted Human Immunodeficiency Virus Type 1 Disease: Intravaginal and Oral Deposition of Simian/Human Immunodeficiency Virus in Macaques Results in Systemic Infection, Elimination
Published in AIDS Weekly, May 26th, 1997
According to the authors' abstract of an article published in Journal of Virology, "Chimeric simian/human immunodeficiency virus (SHIV) consists of the env, vpu, tat, and rev genes of human immunodeficiency virus type 1 (HIV-1) on a background of simian immunodeficiency virus (SN). We derived a SHIV that caused CD4+ cell loss and AIDS in pig-tailed macaques (S.V. Joag, Z. Li, L. Foresman, E.B. Stephens, L.J. Zhao, I. Adany, D. M. Pinson, H.M. McClure, and O. Narayan, J. Virol, 70:3189-3197, 1996) and used a cell-free stock of this virus (SHIVKU-1) to inoculate macaques by the intravaginal route. Macaques developed high virus burdens and severe loss of CD4+ cells...
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Source: AIDS Weekly (1997-05-26)
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